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IHHT® · Intermittent Hypoxic–Hyperoxic Treatment

What is IHHT®?

In IHHT®, phases of reduced oxygen (hypoxic phase) alternate with phases of increased oxygen (hyperoxic recovery phase).

ReOxy® is a respiratory therapy medical device for Intermittent Hypoxic–Hyperoxic Treatment (IHHT®). It delivers alternating hypoxic and hyperoxic gas mixtures.

How dosing works Intended use

improvement of physical exercise capacity in adult and senior patients with coronary artery disease (CAD).

For use in a clinical environment under professional supervision and according to a doctor's prescription.

Exposure and measured response

Illustrative
Schematic: the oxygen exposure alternates between phases while the measured SpO₂ response falls and recovers. Not real data.
Oxygen exposure SpO₂ response
01

The method

Intermittent Hypoxic–Hyperoxic Treatment

The figure shows how the oxygen content of the delivered gas mixture alternates over time.

Alternating phases in IHHT®

Schematic — not device settings
Alternating hypoxic and hyperoxic recovery phases Schematic without values. The oxygen content of the delivered gas mixture steps down during each hypoxic phase and steps up during each hyperoxic recovery phase. Three alternations are shown; phase lengths differ. Hypoxic phase · reduced oxygen Hyperoxic recovery phase · increased oxygen Oxygen in the delivered gas mixture Time
  • Oxygen in the delivered gas mixture
  • Hypoxic phase
  • Hyperoxic recovery phase

Origin of the method

The AiMediq team began developing medical IHHT® at VNIIMI before Ai Mediq S.A. was incorporated in Luxembourg in 2010. The documented sequence includes the 2005 method application, the 2008 response-guided control applications and the later European patent EP 3 452 154 B1.

About AiMediq

02

How dosing works

The measured response determines the individual dose.

The same inspired oxygen concentration can produce a different physiological load in different individuals. The controlled stimulus is guided by the patient’s measured physiological response within clinician-confirmed parameters.

A · BEFORE THE FIRST SESSION

Hypoxic Test

The Hypoxic Test characterises the individual oxygen-saturation and pulse response before treatment. The supervising physician confirms the treatment parameters.

B · THROUGHOUT TREATMENT

SRT® Technology

SRT® Technology uses the measured physiological response to guide hypoxic exposure and hyperoxic recovery throughout the treatment.

A dedicated embedded controller runs SRT® based on 10 different internal sensor measurements.

C · EACH SESSION

Session and cycles

Session duration and the number of cycles are set for the individual treatment plan. Each cycle is guided by the patient’s measured response, and recovery continues until baseline SpO₂ is restored.

Response dynamics during IHHT® cycles

Illustrative reconstruction — not patient data
Illustrative IHHT® cycles Schematic, not real data. Three cycles. In each hypoxic phase the oxygen exposure is lowered and SpO₂ declines; the phases differ in length. In each hyperoxic recovery phase the oxygen exposure is raised and SpO₂ returns to its baseline, where the next cycle begins. Oxygen exposure (FiO₂) Measured response (SpO₂) Hypoxic phase Recovery Baseline SpO₂ Time
  • Oxygen exposure (FiO₂)
  • Measured response (SpO₂)
  • Baseline SpO₂
  • Hypoxic phase
  • Hyperoxic recovery phase

One session at a glance

Illustrative — cycle count and timing vary
Schematic of one session Schematic, not real data. A session timeline divided into six cycles. Each cycle has a hypoxic phase followed by a recovery phase; the lengths of the phases differ from cycle to cycle. One session · illustrative Cycle 1 2 3 4 5 6 Time
  • Hypoxic phase — length varies with the measured response
  • Recovery — until baseline SpO₂ is restored
  • Baseline SpO₂ reached; next cycle begins

Schematic of one session (step C above). The number of cycles and their timing shown here are illustrative.

What ReOxy® measures and the layered safety concept

The ReOxy® device: a white mobile unit with a touchscreen on top and a breathing mask attached to the front.
ReOxy® with breathing mask
03

The device

The ReOxy® device

Measurement, the safety concept, reports, engineering and manufacturing, technical data and documents.

Explore the ReOxy® device Technical data and documents

04

Intended use

improvement of physical exercise capacity in adult and senior patients with coronary artery disease (CAD).

For use in a clinical environment under professional supervision and according to a doctor's prescription.

See the Instructions for Use for contraindications, warnings and precautions.

Availability varies by country.

Contraindications, warnings and precautions

Listed in the Instructions for Use for healthcare professionals.

Contraindications and safety information

Source: ReOxy Instructions for Use TD075530 Rev.9, §§3.3.2–3.3.3. The physician must review the full instructions and the patient’s current condition before treatment.

  • Acute cerebrovascular events within the previous six months
  • Acute forms of ischaemic heart disease, including acute coronary syndrome and myocardial infarction
  • Heart failure NYHA class III–IV
  • Chronic obstructive pulmonary disease or bronchial asthma with significant respiratory distress (SpO₂ below 90%)
  • Renal failure
  • Oncological diseases
  • Systemic diseases
  • Severe psychiatric diseases
  • Individual intolerance to oxygen deficiency
  • Severe systemic non-cardiac disease
  • Acute inflammatory diseases
  • Acute somatic diseases
  • Congenital or acquired defects of the heart and major vessels
  • Severe chronic obstructive pulmonary disease

Patients with silent myocardial ischaemia require ECG monitoring during testing and treatment. Report chest discomfort, headache, dizziness, sleepiness or feeling unwell to the supervising clinical staff. These are possible reactions listed in the IFU; the list does not replace its complete warnings and precautions.

Instructions for Use (HCP)

For patients and families

What happens in a session and questions to ask your doctor.

Information for patients and families
05

Information by role

Where to go next