Cardiology

Indications:
  • Improvement of physical exercise capacity in patients with Coronary Artery Disease NYHA 2-3
  • Chronic Heart Failure (in research)
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Physiological effects:
  • Improves the microcirculation [Belyavskiy et al., Bobyleva et al., Ischuk et al., Townsend et al.]
  • Reduces endothelial dysfunction [Chiu et al. , Elchaninova et al., Haider et al., Manukhina et al.]
  • Decreases the blood pressure [Ainslie et al. , Bailey et al. , Elchaninova et al., Lyamina et al. , Manukhina et al., Shatilo et al.]
  • Increases myocardium and brain resistance to acute ischaemia (precondition-like effect) [Bulgak et al., Zhua et al.]
  • Reduction in the negative consequences of systemic oxidative stress [Arkhipenko et al., Borukaeva et al., Elchaninova et al.]
Clinical Effects:
  • Increases time to fatigue
  • Increases physical endurance
  • Increases VO2 peak
  • Increases %VO2 max
  • Increases Anaerobic threshold
  • Lowers incidence of angina as a reason to stop treadmill run
  • Lowers incidence of ST depression as a reason to stop treadmill run
Lang.TitleYearAuthorsJournalPMID
EngIntermittent Systemic Hypoxic-Hyperoxic Training for Myocardial Protection in Patients Undergoing Coronary Artery Bypass Surgery: First Results From a Single-Centre, Randomised Controlled Trial2018Tuter DS, Kopylov P, Syrkin A, Glazachev O, Komarov R, Katkov A, Severova L, Ivanova E, Zhang Y, Saner HOpen Heart30487981
EngIntermittent Hypoxia–Hyperoxia Conditioning Improves Cardiorespiratory Fitness in Older Comorbid Cardiac Outpatients Without Hematological Changes: A Randomized Controlled Trial2018Dudnik E, Zagaynaya E, Glazachev O, Susta DHIGH ALTITUDE MEDICINE & BIOLOGY30251879
EngAdaptations following an intermittent hypoxia-hyperoxia training in coronary artery disease patients: a controlled study2017Glazachev O, Kopylov P, Susta D, Dudnik E, Zagaynaya EClinical Cardiology28323322
EngA programme based on repeated hypoxia–hyperoxia exposure and light exercise enhances performance in athletes with overtraining syndrome: a pilot study2015Susta D, Glazachev O, Dudnik EClin Physiol Funct Imaging26443707
EngIntermittent hypoxic–hyperoxic training on cognitive performance in geriatric patients2017Bayer U, Likar R, Pinter G, Stettner H, Demschar S, Trummer B, Neuwersch S, Glazachev O, Burtscher MAlzheimer’s & Dementia: Translational Research & Clinical Interventions29067323
EngEffects of intermittent hypoxia-hyperoxia on mobility and perceived health in geriatric patients performing a multimodal training intervention: a randomized controlled trial2019Bayer U, Likar R, Pinter G, Stettner H, Demschar S, Trummer B, Neuwersch S, Glazachev O, Burtscher MBMC Geriatrics31200649
EngHypoxic training: Clinical benefits on cardiometabolic risk factors2014Wee J, Climstein MJ Sci Med Sport.24268571
EngEffect of hypoxic training on inflammatory and metabolic risk factors: a crossover study in healthy subjects.2014Shi B, Watanabe T, Shin S, Yabumoto T, Takemura M, Matsuoka TPhysiol Rep.24744877
EngTrends in the use of preconditioning to hypoxia for early prevention of future life diseases2013Basovich SNBiosci Trends23524890