The intermittent exposure to hypoxia during IHT stimulates epigenetic changes and increased expression of genes that allow adaptation to altitude. The end result of hypoxia adaptation includes improved oxygen, better circulation, improved mitochondrial function, increased tolerance to various stressors and even toxic chemicals, increased antioxidant production and reduced inflammation (Kayser and Verges 2013, Verges, Chacaroun et al. 2015). These adaptive changes can enhance physical and mental capacity, so that the body is better able to cope with a range of stressors and repair and heal cells tissues and organs. (Serebrovskaya, Nikolsky et al. 2011).

IHT increases endothelial production of nitric oxide (NO) while also preventing NO overproduction in the brain and other tissues. The end result is neuroprotection of various pathologies, reduced blood pressure (Lyamina, Lyamina et al. 2011), and a reduction of oxidative stress (Malyshev, Bakhtinia et al. 2001, Manukhina, Downey et al. 2016).

IHT/IHHT effects

Increased tolerance to physical load

Increased VO2 max – maximum rate of oxygen usage
Enhanced power output and speed
Increased exercise-until-exhaustion (ETE) time

Increased tolerance to hypoxia

Reduced possibility of negative effects of the acute hypoxia/ischaemia
Increased myocardium and brain resistance to acute ischaemia (preconditioning effect)

Improved quality of life

Increased activities of daily living
Reduced Depression symptoms
Improved the quality of sleep
Decreased blood pressure and heart rate
Cognitive performance improvement


In patients

Rehabilitation (cardiovascular/pulmonary /spinal cord inquires)
Dementia/ Alzheimer’s disease
Metabolic Disorders (Diabetes Mellitus, Prediabetes,Obesity)
Sport Medicine


Preventive & Anti-aging Medicine
Sport & Fitness
Burnout and exhaustion
Sleep disturbances